RANDOM FOREST MODEL REVEALS THE INTERACTION BETWEEN N6-METHYLADENOSINE MODIFICATIONS AND RNA-BINDING PROTEINS

Summary: RNA-binding proteins (RBPs) have critical roles in N6-methyladenosine (m6A) modification process.We designed a Random Forest (RF) model to systematically analyze the interaction among RBPs and m6A modifications by integrating the binding signals from hundreds of RBPs.Accurate prediction of m6A sites demonstrated significant connections bet

Brain somatic mutations in various components of the mTOR complex 1 (mTORC1) pathway have emerged as major causes of focal malformations of cortical development and intractable epilepsy.While these distinct gene mutations converge on excessive mTORC1 signaling and lead to common clinical manifestations, it remains unclear whether they cause similar